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Curr Mol Med. 2013 May;13(4):543-54.

NFAT gene family in inflammation and cancer.

Author information

1
Division of Oncology and Hematology, Kaiser Permanente Medical Center, Santa Clara, CA 95051, USA. Minggui.Pan@kp.org

Abstract

Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.

PMID:
22950383
PMCID:
PMC3694398
[Indexed for MEDLINE]
Free PMC Article

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