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Case Rep Oncol. 2012 May;5(2):439-43. doi: 10.1159/000342006. Epub 2012 Aug 9.

Primary small cell neuroendocrine carcinoma of the endometrium.

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1
Gynecologic Oncology Associates, Hoag Memorial Hospital Presbyterian, Newport Beach, Calif., USA.

Abstract

BACKGROUND:

Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium.

CASE STUDY:

A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the neoplasm exhibited positive immunoreactivity for synaptophysin, pancytokeratin and CD56 but was negative for CD3 and CD20. Prior to chemotherapy, a completion lymphadenectomy was indicated to determine the presence of nodal metastases.

CONCLUSION:

The prognosis of small cell neuroendocrine carcinoma of the endometrium is unfavorable but prompt detection with surgery and adjuvant therapy may confer a better clinical outcome.

KEYWORDS:

Endometrium; Gynecologic oncology; Small cell neuroendocrine carcinoma

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