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Pediatr Blood Cancer. 2013 Feb;60(2):323-5. doi: 10.1002/pbc.24283. Epub 2012 Sep 4.

Hydroxyurea treatment of children with hemoglobin SC disease.

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1
Baylor College of Medicine and Texas Children's Hematology Center, Houston, Texas, USA. amyates@txch.org

Abstract

The efficacy of hydroxyurea in hemoglobin SC (HbSC) patients is not well documented. We describe the long-term response to hydroxyurea in children with clinically severe HbSC. In 15 patients, hydroxyurea resulted in a significant increase in mean corpuscular volume (MCV) and fetal hemoglobin (HbF) and a significant decrease in episodes of acute chest syndrome and hospitalization for pain; there was no effect on hemoglobin level. The most significant side effect was thrombocytopenia, which led to discontinuation of treatment in one patient. This study suggests that hydroxyurea has efficacy and is safe for long-term therapy in patients with HbSC.

PMID:
22949140
DOI:
10.1002/pbc.24283
[Indexed for MEDLINE]
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