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Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1217-22. doi: 10.1107/S0907444912025772. Epub 2012 Aug 18.

Structure determination of enterovirus 71.

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1
Biological Sciences, Purdue University, West Lafayette, IN 47907-2032, USA.

Abstract

Enterovirus 71 is a picornavirus that causes hand, foot and mouth disease but may induce fatal neurological illness in infants and young children. Enterovirus 71 crystallized in a body-centered orthorhombic space group with two particles in general orientations in the crystallographic asymmetric unit. Determination of the particle orientations required that the locked rotation function excluded the twofold symmetry axes from the set of icosahedral symmetry operators. This avoided the occurrence of misleading high rotation-function values produced by the alignment of icosahedral and crystallographic twofold axes. Once the orientations and positions of the particles had been established, the structure was solved by molecular replacement and phase extension.

PMID:
22948923
PMCID:
PMC3489104
DOI:
10.1107/S0907444912025772
[Indexed for MEDLINE]
Free PMC Article
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