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Cell Mol Life Sci. 2013 Apr;70(8):1381-92. doi: 10.1007/s00018-012-1135-x. Epub 2012 Sep 5.

Chromosomal translocations among the healthy human population: implications in oncogenesis.

Author information

1
Department of Biochemistry, Indian Institute of Science, Bangalore, 560 012, India.

Abstract

Chromosomal translocations are characteristic features of many cancers, especially lymphoma and leukemia. However, recent reports suggest that many chromosomal translocations can be found in healthy individuals, although the significance of this observation is still not clear. In this review, we summarize recent studies on chromosomal translocations in healthy individuals carried out in different geographical areas of the world and discuss the relevance of the observation with respect to oncogenesis.

PMID:
22948164
DOI:
10.1007/s00018-012-1135-x
[Indexed for MEDLINE]

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