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J Laryngol Otol. 2012 Nov;126(11):1091-6. doi: 10.1017/S0022215112001855. Epub 2012 Sep 4.

Effect of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity.

Author information

1
Department of Otolaryngology, Kocaeli University, Turkey. drmurattopdag@yahoo.com

Abstract

OBJECTIVE:

This study aimed to contribute to the literature on the prevention and treatment of ototoxicity due to various drugs and chemicals.

MATERIAL AND METHODS:

This study compared the histological effects of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity, in 36 rats.

RESULTS:

Dexamethasone and memantine had significant effects on the stria vascularis, organ of Corti and spiral ganglion (p < 0.05). Although piracetam decreased the apoptosis rate, this effect was not statistically significant (p > 0.05).

CONCLUSION:

Dexamethasone and memantine were found superior to piracetam in reducing apoptosis due to cisplatin ototoxicity. Further studies of this subject are needed, incorporating electron microscopy and auditory brainstem response testing.

PMID:
22947376
DOI:
10.1017/S0022215112001855
[Indexed for MEDLINE]

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