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Adv Colloid Interface Sci. 2012 Nov 15;183-184:46-54. doi: 10.1016/j.cis.2012.08.002. Epub 2012 Aug 17.

Niosomes: novel sustained release nonionic stable vesicular systems--an overview.

Author information

1
Amrutvahini College of Pharmacy, Sangamner-422608, Dist. Ahmednagar, Maharshtra, India. nitinbmahale@yahoo.com

Abstract

Vesicular systems are novel means of delivering drug in controlled manner to enhance bioavailability and get therapeutic effect over a longer period of time. Niosomes are such hydrated vesicular systems containing nonionic surfactants along with cholesterol or other lipids delivering drug to targeted site which are non toxic, requiring less production cost, stable over a longer period of time in different conditions, so overcomes drawbacks of liposome. Present review describes history, all factors affecting niosome formulation, manufacturing conditions, characterization, stability, administration routes and also their comparison with liposome. This review also gives relevant information regarding various applications of niosomes in gene delivery, vaccine delivery, anticancer drug delivery, etc.

PMID:
22947187
DOI:
10.1016/j.cis.2012.08.002
[Indexed for MEDLINE]

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