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Nat Rev Genet. 2012 Oct;13(10):679-92. doi: 10.1038/nrg3270. Epub 2012 Sep 4.

DNA methylation profiling in the clinic: applications and challenges.

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1
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

Abstract

Knowledge of epigenetic alterations in disease is rapidly increasing owing to the development of genome-wide techniques for their identification. The ever-growing number of genes that show epigenetic alterations in disease emphasizes the crucial role of these epigenetic alterations - particularly DNA methylation - for future diagnosis, prognosis and prediction of response to therapies. This Review focuses on epigenetic profiling, which has started to be of clinical value in cancer and may in the future be extended to other diseases, such as neurological and autoimmune disorders.

PMID:
22945394
DOI:
10.1038/nrg3270
[Indexed for MEDLINE]

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