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Cell Res. 2013 Feb;23(2):179-81. doi: 10.1038/cr.2012.123. Epub 2012 Sep 4.

Microenvironment-mediated resistance to anticancer therapies.

Author information

1
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Resistance to molecularly targeted therapies can result from genomic alterations in the tumor cells that reactivate oncogenic signaling. Less is known of tumor cell-extrinsic mechanisms of resistance to targeted therapies. Two recent studies have identified HGF as a soluble factor capable of mediating resistance to BRAF and HER2 inhibitors in a paracrine manner. These new findings suggest an important role for the tumor microenvironment in mediating resistance to molecularly targeted therapies.

PMID:
22945358
PMCID:
PMC3567818
DOI:
10.1038/cr.2012.123
[Indexed for MEDLINE]
Free PMC Article

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