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Nat Cell Biol. 2012 Sep;14(9):906-8. doi: 10.1038/ncb2570.

Bending membranes.

Author information

1
Department of Cell Biology, Harvard Medical School and Program in Cellular and Molecular Medicine at Boston Children's Hospital, Boston, Massachusetts 02115, USA. kirchhausen@crystal.harvard.edu

Abstract

It is widely assumed that peripheral membrane proteins induce intracellular membrane curvature by the asymmetric insertion of a protein segment into the lipid bilayer, or by imposing shape by adhesion of a curved protein domain to the membrane surface. Two papers now provide convincing evidence challenging these views. The first shows that specific assembly of a clathrin protein scaffold, coupled to the membrane, seems to be the most prevalent mechanism for bending a lipid bilayer in a cell. The second reports that membrane crowding, driven by protein-protein interactions, can also drive membrane bending, even in the absence of any protein insertion into the bilayer.

PMID:
22945258
DOI:
10.1038/ncb2570
[Indexed for MEDLINE]

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