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Biol Chem. 2012 Aug;393(8):661-73. doi: 10.1515/hsz-2012-0150.

Complicated N-linked glycans in simple organisms.

Author information

1
Department für Chemie, Universität für Bodenkultur, A-1190 Wien, Austria.

Abstract

Although countless genomes have now been sequenced, the glycomes of the vast majority of eukaryotes still present a series of unmapped frontiers. However, strides are being made in a few groups of invertebrate and unicellular organisms as regards their N-glycans and N-glycosylation pathways. Thereby, the traditional classification of glycan structures inevitably approaches its boundaries. Indeed, the glycomes of these organisms are rich in surprises, including a multitude of modifications of the core regions of N-glycans and unusual antennae. From the actually rather limited glycomic information we have, it is nevertheless obvious that the biotechnological, developmental and immunological relevance of these modifications, especially in insect cell lines, model organisms and parasites means that deciphering unusual glycomes is of more than just academic interest.

PMID:
22944671
PMCID:
PMC3589692
DOI:
10.1515/hsz-2012-0150
[Indexed for MEDLINE]
Free PMC Article

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