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Biol Chem. 2012 Jul;393(7):641-6. doi: 10.1515/hsz-2012-0107.

Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides' connection with antimicrobial peptides.

Author information

1
Key Laboratory of Bioorganic Phosphorus Chemistry andChemical Biology (Ministry of Education), Department ofChemistry, Tsinghua University, Beijing, China.

Abstract

Human islet amyloid polypeptide (hIAPP) shows an antimicrobial activity towards two types of clinically relevant bacteria. The potency of hIAPP varies with its aggregation states. Circular dichroism was employed to determine the interaction between hIAPP and bacteria lipid membrane mimic. The antimicrobial activity of each aggregate species is associated with their ability to induce membrane disruption. Our findings provide new evidence revealing the antimicrobial activity of amyloid peptide, which suggest a possible connection between amyloid peptides and antimicrobial peptides.

PMID:
22944668
DOI:
10.1515/hsz-2012-0107
[Indexed for MEDLINE]

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