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Pathog Glob Health. 2012 May;106(2):107-12. doi: 10.1179/2047773212Y.0000000002.

Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.

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1
Universidade Estadual de Londrina, Londrina, Paraná, Brazil.

Abstract

We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2·2·1]heptan-2-yl-3',4',5'-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2·2·1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs(50/72h) of two synthetic L-bornyl benzoates, 1 and 2, was 10·1 and 12·8 μg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections.

PMID:
22943546
PMCID:
PMC4001496
DOI:
10.1179/2047773212Y.0000000002
[Indexed for MEDLINE]
Free PMC Article
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