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J Travel Med. 2012 Sep-Oct;19(5):308-10. doi: 10.1111/j.1708-8305.2012.00636.x. Epub 2012 Jul 30.

Tadalafil and acetazolamide versus acetazolamide for the prevention of severe high-altitude illness.

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1
Center for Geographic Medicine and Internal Medicine C, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel Aviv, Israel.

Abstract

We report an open-label study comparing tadalafil and acetazolamide (n = 24) versus acetazolamide (n = 27) for prevention of high-altitude illness (HAI) at Mt. Kilimanjaro. Tadalafil group had lower rates of severe HAI compared with controls (4% vs 26%, p = 0.03), mostly because of decreased high-altitude pulmonary edema rates (4% vs 22%, p = 0.06).

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