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Int J Mol Sci. 2012;13(7):8142-58. doi: 10.3390/ijms13078142. Epub 2012 Jul 2.

Effects of purified Saccharomyces cerevisiae (1→3)-β-glucan on venous ulcer healing.

Author information

1
Laboratory of Clinical Immunology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Farias Ave., Petrópolis, Natal, RN 59012-570, Brazil; E-Mails: sarah_farma@hotmail.com (S.D.V.M.); jessy_ecc@hotmail.com (J.E.C.C.); karinamelchuna@yahoo.com.br (K.M.M.); aleida_maria85@yahoo.com.br (A.M. S.L.).

Abstract

Water-insoluble glucan was isolated from the baker's yeast Saccharomyces cerevisiae. The yeast cells were treated with alkali and the residue then with acid. Chemical and NMR (1D and 2D) analyses showed that a linear (1→3)-β-glucan was purified that was not contaminated with other carbohydrates, proteins or phenolic compounds. The effects of the glucan on wound healing were assessed in human venous ulcers by histopathological analysis after 30 days of topical treatment. (1→3)-β-glucan enhanced ulcer healing and increased epithelial hyperplasia, as well as increased inflammatory cells, angiogenesis and fibroblast proliferation. In one patient who had an ulcer that would not heal for over 15 years, glucan treatment caused a 67.8% decrease in the area of the ulcer. This is the first study to investigate the effects of (1→3)-β-glucan on venous ulcer healing in humans; our findings suggest that this glucan is a potential natural biological response modifier in wound healing.

KEYWORDS:

immunomodulator; polysaccharide; tissue repair; water-insoluble glucan; yeast

PMID:
22942695
PMCID:
PMC3430226
DOI:
10.3390/ijms13078142
[Indexed for MEDLINE]
Free PMC Article
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