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Nat Neurosci. 2012 Oct;15(10):1439-44. doi: 10.1038/nn.3203. Epub 2012 Sep 2.

Biasing the content of hippocampal replay during sleep.

Author information

1
Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. dbendor@mit.edu

Abstract

The hippocampus is essential for encoding self-experienced events into memory. During sleep, neural activity in the hippocampus related to a recent experience has been observed to spontaneously reoccur, and this 'replay' has been postulated to be important for memory consolidation. Task-related cues can enhance memory consolidation when presented during a post-training sleep session, and, if memories are consolidated by hippocampal replay, a specific enhancement for this replay should be observed. To test this, we trained rats on an auditory-spatial association task while recording from neuronal ensembles in the hippocampus. We found that, during sleep, a task-related auditory cue biased reactivation events toward replaying the spatial memory associated with that cue. These results indicate that sleep replay can be manipulated by external stimulation and provide further evidence for the role of hippocampal replay in memory consolidation.

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PMID:
22941111
PMCID:
PMC4354843
DOI:
10.1038/nn.3203
[Indexed for MEDLINE]
Free PMC Article

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