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Nat Neurosci. 2012 Oct;15(10):1368-70. doi: 10.1038/nn.3210. Epub 2012 Sep 2.

Saccadic eye movements evoked by optogenetic activation of primate V1.

Author information

1
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA. mjaz@u.washington.edu

Abstract

Optogenetics has advanced our understanding of the neural basis of simple behaviors in rodents and small animals. In primates, however, for which more sophisticated behavioral assays exist, optogenetic manipulations of behavior have been unsuccessful. We found that monkeys reliably shifted their gaze toward the receptive field of optically driven channelrhodopsin-2-expressing neurons of the primary visual cortex. This result establishes optogenetics as a viable tool for the causal analysis of behavior in primate brain.

PMID:
22941109
PMCID:
PMC3458167
DOI:
10.1038/nn.3210
[Indexed for MEDLINE]
Free PMC Article

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