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Bioorg Med Chem Lett. 2012 Oct 1;22(19):6136-8. doi: 10.1016/j.bmcl.2012.08.030. Epub 2012 Aug 14.

Chitooligosaccharides induce apoptosis in human myeloid leukemia HL-60 cells.

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Department of Food Life Science, Konkuk University, Chungju 380-701, Republic of Korea.


In this study we propose a novel anticancer agent using hetero-chitooligosaccharide (hetero-COS). To examine the possibility of the hetero-COS as a anticancer agent, we prepared nine kinds of hetero-COS with relatively higher molecular weights (90, 75 and 50-COS I, 5-10kDa), medium molecular weights (90, 75 and 50-COS II, 1-5kDa), and lower molecular weights (90, 75 and 50-III, below 1kDa), and their anticancer properties were investigated on HL-60 cells using flow cytometry and morphological analysis. The results obtained indicate that 90-COS III, which is relatively higher degree of deacetylation and lower molecular weights, showed the highest anticancer activity, and the data showed the anticancer property of the hetero-COSs depended on their degree of deacetylation values and molecular weight.

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