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FEBS Lett. 2012 Oct 19;586(20):3548-54. doi: 10.1016/j.febslet.2012.08.018. Epub 2012 Aug 31.

Structural considerations for chromatin state models with transcription as a functional readout.

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1
Department of Anesthesiology, David Geffen School of Medicine at UCLA, United States.

Abstract

Lacking from the rapidly evolving field of chromatin regulation is a discrete model of chromatin states. We propose that each state in such a model should meet two conditions: a structural component and a quantifiable effect on transcription. The practical benefits to the field of a model with greater than two states (including one with six states, as described herein) would be to improve interpretation of data from disparate organ systems, to reflect temporal and developmental dynamics and to integrate the, at present, conceptually and experimentally disparate analyses of individual genetic loci (in vitro or using single gene approaches) and genome-wide features (including ChlP-seq, chromosomal capture and mRNA expression via microarrays/sequencing).

PMID:
22940112
PMCID:
PMC3495570
DOI:
10.1016/j.febslet.2012.08.018
[Indexed for MEDLINE]
Free PMC Article
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