Format

Send to

Choose Destination
Am J Obstet Gynecol. 2012 Sep;207(3):192.e1-9. doi: 10.1016/j.ajog.2012.06.059. Epub 2012 Jul 7.

Brain damage in preterm newborns and maternal medication: the ELGAN Study.

Author information

1
Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing, MI, USA.

Abstract

OBJECTIVE:

We sought to evaluate the association between maternal medication use during pregnancy and cerebral white matter damage and cerebral palsy (CP) among very preterm infants.

STUDY DESIGN:

This analysis of data from the Extremely Low Gestational Age Newborns (ELGAN) Study included 877 infants born <28 weeks' gestation. Mothers were interviewed, charts were reviewed, placentas were cultured and assessed histologically, and children were evaluated at 24 months corrected age. A diagnostic algorithm classified neurologic findings as quadriparetic CP, diparetic CP, hemiparetic CP, or no CP.

RESULTS:

After adjustment for the potential confounding of disorders for which medications might have been indicated, the risk of quadriparetic CP remained elevated among the infants of mothers who consumed aspirin (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.3-6.9) and nonsteroidal antiinflammatory drugs (NSAIDs) (OR, 2.4; 95% CI, 1.04-5.8). The risk of diparetic CP was also associated with maternal consumption of an NSAID, but only if the consumption was not approved by a physician (OR, 3.5; 95% CI 1.1-11.0).

CONCLUSION:

The possibility that aspirin and NSAID use in pregnancy could lead to perinatal brain damage cannot be excluded.

PMID:
22939723
PMCID:
PMC3432943
DOI:
10.1016/j.ajog.2012.06.059
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center