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Am J Obstet Gynecol. 2012 Sep;207(3):188.e1-9. doi: 10.1016/j.ajog.2012.06.083. Epub 2012 Jul 7.

Abnormal vascular architecture at the placental-maternal interface in placenta increta.

Author information

1
Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire, Hôpital la Citadelle, Liège, Belgium. fchantraine@chu.ulg.ac.be

Abstract

OBJECTIVE:

The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies.

STUDY DESIGN:

Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections.

RESULTS:

The total areas occupied by vessels in normal and placenta-increta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta-vessel distributions (area and distance from the placental-myometrial junction) were more heterogeneous.

CONCLUSION:

Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.

PMID:
22939721
DOI:
10.1016/j.ajog.2012.06.083
[Indexed for MEDLINE]

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