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Cell. 2012 Aug 31;150(5):873-5. doi: 10.1016/j.cell.2012.08.008.

Singles engage the RNA interference pathway.

Abstract

Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.

PMID:
22939614
DOI:
10.1016/j.cell.2012.08.008
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