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Am J Epidemiol. 1990 Jan;131(1):177-84.

Sample size requirements for interval estimation of the odds ratio.

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Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.

Erratum in

  • Am J Epidemiol 1990 Mar;131(3):578.
  • Am J Epidemiol 1990 Jun;131(6):1102.


Sample sizes are calculated for unmatched case-control (or cohort) studies where the goal is interval estimation of the odds ratio. The procedure used gives the smallest sample size for which a 100(1-alpha)% confidence interval for the log odds ratio will not exceed a specified width with specified probability (1-gamma). Tables of sample sizes for various choices of parameter values are presented. Considerable disagreement is found with a published method which has as its basis expected cell counts.

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