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Front Neurosci. 2012 Aug 21;6:122. doi: 10.3389/fnins.2012.00122. eCollection 2012.

Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function.

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FAS Center for Systems Biology, Harvard University Cambridge, MA, USA.


Alternative pre-mRNA splicing has the potential to greatly diversify the repertoire of transcripts in multicellular organisms. Increasing evidence suggests that this expansive layer of gene regulation plays a particularly important role in the development and function of the nervous system, one of the most complex organ systems found in nature. In this review, we highlight recent studies that continue to emphasize the influence and contribution of alternative splicing regulation to various aspects of neuronal development in addition to its role in the mature nervous system.


RNA processing; alternative splicing; gene regulation; genomics; nervous system

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