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Angew Chem Int Ed Engl. 2012 Sep 24;51(39):9914-7. doi: 10.1002/anie.201203219. Epub 2012 Aug 31.

Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase.

Author information

1
Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.

Erratum in

  • Angew Chem Int Ed Engl. 2012 Nov 26;51(48):11924.

Abstract

Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.

PMID:
22936647
DOI:
10.1002/anie.201203219
[Indexed for MEDLINE]

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