Zidovudine disposition during hemodialysis in a patient with acquired immunodeficiency syndrome

J Acquir Immune Defic Syndr (1988). 1990;3(1):32-4.

Abstract

Zidovudine (azidothymidine, AZT) disposition was examined during a hemodialysis session in an HIV-infected male with mesangial proliferative glomerulonephritis. Serum concentrations of zidovudine and its glucuronidated inactive metabolite (G-ZDV) were measured by HPLC. Zidovudine pharmacokinetics were similar to previous reports in patients with normal renal function, however, G-ZDV concentrations were significantly elevated (23-440 times zidovudine concentration). Hemodialysis did not appreciably reduce zidovudine or G-ZDV levels. Significance of chronically elevated G-ZDV levels is unknown.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Adult
  • Chromatography, High Pressure Liquid
  • Glomerulonephritis, Membranoproliferative / complications
  • Glomerulonephritis, Membranoproliferative / therapy
  • Humans
  • Male
  • Renal Dialysis*
  • Zidovudine / blood*
  • Zidovudine / therapeutic use

Substances

  • Zidovudine