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Comb Chem High Throughput Screen. 2013 Mar;16(3):180-8.

New informatics and automated infrastructure to accelerate new leads discovery by high throughput screening (HTS).

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Lankenau Institute for Medical Research Chemical Genomics Center-LCGC, Inc., 100 Lancaster Avenue, Wynnewood, PA 19096, USA.


The Lankenau Institute for Medical Research Chemical Genomics Center, Inc. has developed a new (patents issued and pending) Nanotube Automated Repository System (NARS) for dynamic storage of millions of 'single-shot' samples stored in a new monolithic microtiter-storage tube plate of our own design we call 'nanotubes.' We have integrated the NARS with customized software to efficiently access up to 10,000,000 samples stored continuously frozen (-20°C) in a dehumidified enclosure and sealed in a new microtiter NARS plate that is SBS compliant. Additional software was developed to analyze HTS data from orthogonally pooled compound libraries. Following 'de-convolution' of pooled HTS data, the software designates confirmatory retest samples to be 'cherry-picked' using the NARS. The application of a new, fully-integrated infrastructure for new leads discovery is described in detail. Other applications for our technologies and new infrastructure are discussed.

[Indexed for MEDLINE]

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