Format

Send to

Choose Destination
J Intern Med. 2012 Nov;272(5):440-8. doi: 10.1111/j.1365-2796.2012.02587.x. Epub 2012 Oct 11.

Twins and the mystery of missing heritability: the contribution of gene-environment interactions.

Author information

1
Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland. jaakko.kaprio@helsinki.fi

Abstract

Since 2006, the advent of increasingly larger genome-wide association studies and their meta-analyses have led to numerous, replicated findings of genetic polymorphisms associated with many diseases and traits. Early studies suggested that the identified loci generally accounted for a small fraction of the genetic variance estimated from twin and family studies. This led to the concept of 'missing heritability'. Here, the progress in accounting for a greater proportion of the variance is reviewed. In particular, gene-environment interactions can, for some traits and in certain circumstances, explain part of this missing heritability.

PMID:
22934540
PMCID:
PMC4422871
DOI:
10.1111/j.1365-2796.2012.02587.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center