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Radiol Oncol. 2010 Mar;44(1):57-61. doi: 10.2478/v10019-010-0005-0. Epub 2010 Mar 18.

Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines.

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Mayo Medical School, College of Medicine, Mayo Clinic, Rochester, Minnesota.



Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis.


We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer.


This case underscores the importance of following cancer-screening guidelines.


MYH-associated polyposis; adenomatous polyposis coli; attenuated familial adenomatous polyposis; colorectal cancer; familial adenomatous polyposis; microsatellite instability

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