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Biochemistry. 2012 Sep 25;51(38):7420-32. doi: 10.1021/bi300758e. Epub 2012 Sep 10.

From mechanical force to RhoA activation.

Author information

1
Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

Throughout their lives, all cells constantly experience and respond to various mechanical forces. These frequently originate externally but can also arise internally as a result of the contractile actin cytoskeleton. Mechanical forces trigger multiple signaling pathways. Several converge and result in the activation of the GTPase RhoA. In this review, we focus on the pathways by which mechanical force leads to RhoA regulation, especially when force is transmitted via cell adhesion molecules that mediate either cell-matrix or cell-cell interactions. We discuss both the upstream signaling events that lead to activation of RhoA and the downstream consequences of this pathway. These include not only cytoskeletal reorganization and, in a positive feedback loop, increased myosin-generated contraction but also profound effects on gene expression and differentiation.

PMID:
22931484
PMCID:
PMC3567302
DOI:
10.1021/bi300758e
[Indexed for MEDLINE]
Free PMC Article

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