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Mol Endocrinol. 2012 Oct;26(10):1651-9. Epub 2012 Aug 28.

Minireview: applications of next-generation sequencing on studies of nuclear receptor regulation and function.

Author information

1
Department of Biostatistics and Computational Biology, Harvard School of Public Health, Biostatistics and Computational Biology, 450 Brookline Street, Boston, Massachusetts 02215, USA.

Abstract

Next-generation sequencing technologies have expanded the experimental possibilities for studying the genome-wide regulation of transcription by nuclear receptors, their collaborating transcription factors, and coregulators. These technologies allow investigators to obtain abundance and DNA sequence information in a single experiment. In this review, we highlight proven and potential uses of next-generation sequencing in the study of gene regulation by nuclear receptors. We also provide suggestions on how to effectively leverage this technology in a collaborative environment.

PMID:
22930692
PMCID:
PMC3458226
DOI:
10.1210/me.2012-1150
[Indexed for MEDLINE]
Free PMC Article

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