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ChemMedChem. 2012 Oct;7(10):1763-9. doi: 10.1002/cmdc.201200321. Epub 2012 Aug 28.

Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family.

Author information

1
Ion Channel Biotechnology Centre, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth, Ireland.

Abstract

Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.

PMID:
22930560
DOI:
10.1002/cmdc.201200321
[Indexed for MEDLINE]

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