Format

Send to

Choose Destination
Br J Cancer. 2012 Sep 25;107(7):1188-94. doi: 10.1038/bjc.2012.374. Epub 2012 Aug 28.

Quantitative relationship between silica exposure and lung cancer mortality in German uranium miners, 1946-2003.

Author information

1
Department of Radiation Protection and Health, BfS, Federal Office for Radiation Protection, Neuherberg 85764, Germany. msogl@bfs.de

Abstract

BACKGROUND:

In 1996 and 2009, the International Agency for Research on Cancer classified silica as carcinogenic to humans. The exposure-response relationship between silica and lung cancer risk, however, is still debated. Data from the German uranium miner cohort study were used to further investigate this relationship.

METHODS:

The cohort includes 58677 workers with individual information on occupational exposure to crystalline silica in mg m(-3)-years and the potential confounders radon and arsenic based on a detailed job-exposure matrix. In the follow-up period 1946-2003, 2995 miners died from lung cancer. Internal Poisson regression with stratification by age and calendar year was used to estimate the excess relative risk (ERR) per dust-year. Several models including linear, linear quadratic and spline functions were applied. Detailed adjustment for cumulative radon and arsenic exposure was performed.

RESULTS:

A piecewise linear spline function with a knot at 10 mg m(-3)-years provided the best model fit. After full adjustment for radon and arsenic no increase in risk <10 mg m(-3)-years was observed. Fixing the parameter estimate of the ERR in this range at 0 provided the best model fit with an ERR of 0.061 (95% confidence interval: 0.039, 0.083) >10 mg m(-3)-years.

CONCLUSION:

The study confirms a positive exposure-response relationship between silica and lung cancer, particularly for high exposures.

PMID:
22929885
PMCID:
PMC3461166
DOI:
10.1038/bjc.2012.374
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center