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Methods Enzymol. 2012;513:315-34. doi: 10.1016/B978-0-12-391938-0.00014-8.

A chemical approach to mapping nucleosomes at base pair resolution in yeast.

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  • 1Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.


Most eukaryotic DNA exists in DNA-protein complexes known as nucleosomes. The exact locations of nucleosomes along the genome play a critical role in chromosome functions and gene regulation. However, the current methods for nucleosome mapping do not provide the necessary accuracy to identify the precise nucleosome locations. Here we describe a new experimental approach that directly maps nucleosome center locations in vivo genome-wide at single base pair resolution.

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