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Clin Chest Med. 2012 Sep;33(3):431-43. doi: 10.1016/j.ccm.2012.05.005. Epub 2012 Jul 7.

Genetics of asthma susceptibility and severity.

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1
Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Abstract

This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.

PMID:
22929093
PMCID:
PMC3431509
DOI:
10.1016/j.ccm.2012.05.005
[Indexed for MEDLINE]
Free PMC Article
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