Format

Send to

Choose Destination
See comment in PubMed Commons below
Nano Lett. 2012 Sep 12;12(9):4830-7. doi: 10.1021/nl302273p. Epub 2012 Sep 4.

Intercellular carbon nanotube translocation assessed by flow cytometry imaging.

Author information

1
CNRS/Université Paris Diderot, PRES Sorbonne-Paris Cité, Laboratoire Matière et Systèmes Complexes (MSC), UMR7057, 75205 Paris cedex 13, France.

Abstract

The fate of carbon nanotubes in the organism is still controversial. Here, we propose a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells. We give the first experimental evidence of an intercellular translocation of carbon nanotubes. This stress-induced longitudinal transfer of nanomaterials is mediated by cell-released microvesicles known as vectors for intercellular communication. This finding raises new critical issues for nanotoxicology, since carbon nanotubes could be disseminated by circulating extracellular cell-released vesicles and visiting several cells in the course of their passage into the organism.

PMID:
22928721
DOI:
10.1021/nl302273p
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center