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Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15036-41. doi: 10.1073/pnas.1207768109. Epub 2012 Aug 27.

Human blood metabolite timetable indicates internal body time.

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1
Functional Genomics Unit, RIKEN Center for Developmental Biology, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

Abstract

A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. Our minimally invasive, molecular-timetable method with human blood enables highly optimized and personalized medicine.

PMID:
22927403
PMCID:
PMC3443163
DOI:
10.1073/pnas.1207768109
[Indexed for MEDLINE]
Free PMC Article
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