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J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1096-8.

Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.

Author information

1
Department of Neurology, King's College Hospital, London, United Kingdom.

Abstract

Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM either intravenously or orally is associated with a significant rise of CSF SAM, indicating that it crosses the blood-brain barrier in humans. These observations provide a rational basis for the antidepressant effect of SAM, which has been confirmed in several countries. CSF SAM levels were low in a group of patients with Alzheimer's dementia suggesting a possible disturbance of methylation in such patients and the need for trials of SAM treatment.

PMID:
2292704
PMCID:
PMC488323
DOI:
10.1136/jnnp.53.12.1096
[Indexed for MEDLINE]
Free PMC Article

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