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Angew Chem Int Ed Engl. 2012 Sep 24;51(39):9877-80. doi: 10.1002/anie.201204992. Epub 2012 Aug 24.

Total syntheses of amphidinolides B, G, and H.

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1
Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.

Abstract

Not one, not two, but three: Total syntheses of amphidinolides B, G, and H, which exhibit strong, nanogram-scale cytotoxicity against various tumor cell lines, have been executed. The synthetic strategy relied on implementation of a diene construction protocol and a diastereoselective aldol process. The 26- and 27-membered macrocyclic lactone rings were efficiently constructed by using ring-closing metathesis (RCM).

PMID:
22927025
DOI:
10.1002/anie.201204992
[Indexed for MEDLINE]
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