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Ann Neurol. 2012 Aug;72(2):156-66. doi: 10.1002/ana.23647.

Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy.

Author information

1
Department of Neurology, Harvard Medical School, Children's Hospital Boston, Boston, MA 02115, USA. Joseph.volpe@childrens.harvard.edu

Abstract

This Point of View article addresses neonatal encephalopathy (NE) presumably caused by hypoxia-ischemia and the terminology currently in wide use for this disorder. The nonspecific term NE is commonly utilized for those infants with the clinical and imaging characteristics of neonatal hypoxic-ischemic encephalopathy (HIE). Multiple magnetic resonance imaging studies of term infants with the clinical setting of presumed hypoxia-ischemia near the time of delivery have delineated a topography of lesions highly correlated with that defined by human neuropathology and by animal models, including primate models, of hypoxia-ischemia. These imaging findings, coupled with clinical features consistent with perinatal hypoxic-ischemic insult(s), warrant the specific designation of neonatal HIE.

PMID:
22926849
DOI:
10.1002/ana.23647
[Indexed for MEDLINE]

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