Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Psychopharmacol. 2012 Oct;32(5):694-8.

Akathisia and suicidal ideation in first-episode schizophrenia.

Author information

1
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany. fseemuel@med.lmu.de

Abstract

Patients with first-episode schizophrenia (FES) are known to be notably sensitive for developing extrapyramidal adverse effects, but the relation of akathisia and suicidal ideation has rarely been studied. The current report is an ongoing analysis of an 8-week double-blind randomized controlled multicenter trial in 289 FES, comparing risperidone and haloperidol. Assessments were conducted weekly and included the Hillside Akathisia Scale and 21-item Hamilton Depression Rating Scale ratings. Suicidal ideation was significantly associated with clinician observed akathisia, depressed mood, younger age, and use of propranolol. The allocated treatment, anxiety, and nervousness had no influence. The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00159120.

PMID:
22926606
DOI:
10.1097/JCP.0b013e3182677958
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center