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Adv Drug Deliv Rev. 2012 Nov;64(14):1628-38. doi: 10.1016/j.addr.2012.08.006. Epub 2012 Aug 19.

MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications.

Author information

1
Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, DRB-140, Los Angeles, CA 90089-1111, USA. ellis.meng@usc.edu

Abstract

Innovation in implantable drug delivery devices is needed for novel pharmaceutical compounds such as certain biologics, gene therapy, and other small molecules that are not suitable for administration by oral, topical, or intravenous routes. This invasive dosing scheme seeks to directly bypass physiological barriers presented by the human body, release the appropriate drug amount at the site of treatment, and maintain the drug bioavailability for the required duration of administration to achieve drug efficacy. Advances in microtechnologies have led to novel MEMS-enabled implantable drug infusion pumps with unique performance and feature sets. In vivo demonstration of micropumps for laboratory animal research and preclinical studies include acute rapid radiolabeling, short-term delivery of nanomedicine for cancer treatment, and chronic ocular drug dosing. Investigation of MEMS actuators, valves, and other microstructures for on-demand dosing control may enable next generation implantable pumps with high performance within a miniaturized form factor for clinical applications.

PMID:
22926321
PMCID:
PMC3488150
DOI:
10.1016/j.addr.2012.08.006
[Indexed for MEDLINE]
Free PMC Article

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