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Fertil Steril. 2012 Dec;98(6):1458-63. doi: 10.1016/j.fertnstert.2012.07.1135. Epub 2012 Aug 25.

Limited implantation success of direct-cleaved human zygotes: a time-lapse study.

Author information

1
Instituto Valenciano de Infertilidad Valencia, Universidad de Valencia, Valencia, Spain.

Abstract

OBJECTIVE:

To evaluate embryos with direct cleavage (≤5 hours) from two to three cells (DC2-3) and correlate this morphokinetic parameter to implantation and ongoing pregnancy.

DESIGN:

Clinical multicenter retrospective study.

SETTING:

Private in vitro fertilization (IVF) centers.

PATIENT(S):

From three clinics, a total of 979 treatments including 5,225 embryos using autologous or donated oocytes, of which 1,659 embryos were transferred.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Clinical pregnancy confirmed by ultrasound in week 7.

RESULT(S):

Of the total embryo cohort, 715 (13.7%) underwent direct cleavage from two to three cells, 1,659 embryos were transferred to recipients, and 109 of the transferred embryos cleaved directly from two to three cells (6.6%). Only one DC2-3 embryo was known to result in a clinical pregnancy (1%) and 80 (73.4%) DC2-3 embryos did not implant. Of the 1,550 embryos transferred not showing DC2-3, 203 embryos were from treatments with 100% implantation (13.1%), and 804 (51.8%) embryos did not implant. The known implantation rate of DC2-3 embryos was statistically significantly lower than for embryos with a normal cleavage pattern (1.2% vs. 20.2%, respectively).

CONCLUSION(S):

Embryos with DC2-3 had a statistically significantly lower implantation rate than embryos with a normal cleavage pattern, suggesting that rejection of these embryos for transfer could improve the implantation rate.

[Indexed for MEDLINE]

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