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Fertil Steril. 2012 Dec;98(6):1490-4. doi: 10.1016/j.fertnstert.2012.07.1136. Epub 2012 Aug 25.

Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy.

Author information

1
Fertility Center of Las Vegas, Las Vegas, Nevada 89117, USA. bsshapiro@aol.com

Abstract

OBJECTIVE:

To compare the incidence of ectopic pregnancy (EP) after fresh ET and thawed ET.

DESIGN:

Retrospective cohort study.

SETTING:

Private fertility center.

PATIENT(S):

This retrospective study included 2,150 blastocyst transfers, including all 1,460 fresh autologous blastocyst transfers and all 690 transfers of autologous blastocysts derived from post-thaw extended culture of thawed bipronuclear oocytes in the 8-year study period 2004-2011.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Visualized EP and treated persistent pregnancy of unknown location.

RESULT(S):

The rate of visualized EP was 1.5% in pregnancies in fresh autologous cycles, which was significantly more than the rate of 0 with autologous post-thaw extended culture. The rates of treated persistent pregnancy of unknown location were 2.5% and 0.3% in these two groups, respectively, a difference that was also statistically significant (relative risk 7.3, 95% confidence interval 1.7-31.0).

CONCLUSION(S):

Relative to fresh transfer, thawed ET was associated with significantly reduced incidence of EP. These findings are consistent with ovarian stimulation increasing the risk of EP.

[Indexed for MEDLINE]

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