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Acta Paediatr. 2012 Dec;101(12):1211-6. doi: 10.1111/j.1651-2227.2012.02826.x. Epub 2012 Sep 10.

Low postnatal serum IGF-I levels are associated with bronchopulmonary dysplasia (BPD).

Author information

1
Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. chatarina.lofqvist@gu.se

Abstract

AIM:

To characterize postnatal changes in serum insulin-like growth factor-1 (IGF-I) in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants.

METHODS:

Longitudinal study of 108 infants with mean (SD) gestational age (GA) 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analysed from birth until postmenstrual age (PMA) 36 weeks. Multivariate models were developed to identify independent predictors of BPD.

RESULTS:

Postnatal mean IGF-I levels at postnatal day (PND) 3-21 were lower in infants with BPD compared with infants with no BPD (16 vs. 26 μg/L, p < 0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β)), PNDs 3-21, was lower in infants with BPD compared with infants with no BPD (0.28 vs. 0.97, p = 0.002) and mean IGF-I during PMA 30-33 weeks was lower in infants with BPD as compared with infants without BPD (22 vs. 29 μg/L, p < 0.001). In a binomial multiple regression model, lower GA, male gender and lower mean serum IGF-I levels during PND 3-21 were the most predictive risk factors associated with BPD (r(2) = 0.634, p < 0.001).

CONCLUSION:

Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD.

PMID:
22924869
PMCID:
PMC3569611
DOI:
10.1111/j.1651-2227.2012.02826.x
[Indexed for MEDLINE]
Free PMC Article

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