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J Lab Physicians. 2012 Jan;4(1):59-61. doi: 10.4103/0974-2727.98679.

Florid erythrophagocytosis on the peripheral smear.

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Department of Hematology, Apollo Hospitals, 21, Greams Lane, Off Greams Road, Chennai, Tamil Nadu, India.


Erythrophagocytosis is a relatively rare observation on blood smears. It has been reported in auto immune hemolytic anemias and sporadically in few other conditions. Here, we report a case of florid erythrophagocytosis with severe anemia following a viral infection in an 18-year-old girl. Her complete blood count (CBC) revealed hemoglobin of 3.6 gm/dl and a hematocrit of 10%. The peripheral smear showed erythrophagocytosis by neutrophils and rosetting of erythrocytes around neutrophils. The direct Coombs test and direct Donath- Landsteiner tests were positive.


Autoimmune hemolytic anemia; Donath-Landsteiner test; erythrophagocytosis; paroxysmal cold hemoglobinuria

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