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Dement Geriatr Cogn Disord. 2012;34(2):69-74. Epub 2012 Aug 23.

The evaluation of neutrophil-lymphocyte ratio in Alzheimer's disease.

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Department of Internal Medicine, Division of Geriatric Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey.



There is growing consensus in the literature that inflammation plays a significant role in the pathophysiology of Alzheimer's disease (AD). The blood neutrophil-lymphocyte ratio (NLR) is a new, inexpensive and easily applicable marker of inflammation. The aim of this study was to investigate the association between NLR, as an inflammatory biomarker, and AD.


241 AD patients and 175 patients with normal cognitive function were evaluated in this study.


The mean ± SD NLR of AD patients was significantly higher than that of patients with normal cognitive function (3.21 ± 1.35 vs. 2.07 ± 0.74, p < 0.001, respectively). Receiver operating characteristic curve analysis suggested that the optimum NLR cutoff point for AD was 2.48 with 69.29% sensitivity, 79.43% specificity, 82.30% positive predictive values and 65.30% negative predictive values. Logistic regression analysis showed that elevated NLR (OR: 4.774, 95% CI: 2.821-8.076, p < 0.001) was an independent variable for predicting AD.


Elderly people with AD have higher NLR than healthy controls. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of AD.

[Indexed for MEDLINE]

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