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Cell Metab. 2012 Sep 5;16(3):290-5. doi: 10.1016/j.cmet.2012.06.016. Epub 2012 Aug 23.

The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease.

Author information

1
Department of Medical Chemistry, University of Debrecen, Medical and Health Science Center, Debrecen 4032, Hungary. baip@med.unideb.hu

Abstract

While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.

PMID:
22921416
DOI:
10.1016/j.cmet.2012.06.016
[Indexed for MEDLINE]
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