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Immunity. 2012 Aug 24;37(2):199-207. doi: 10.1016/j.immuni.2012.08.002.

Regulation of humoral immunity by complement.

Author information

1
Immune Disease Institute and Program in Molecular and Cellular Medicine, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, 02115 MA, USA. carroll@idi.harvard.edu

Abstract

The complement system of innate immunity is important in regulating humoral immunity largely through the complement receptor CR2, which forms a coreceptor on B cells during antigen-induced activation. However, CR2 also retains antigens on follicular dendritic cells (FDCs). Display of antigen on FDCs is critical for clonal selection and affinity maturation of activated B cells. This review will discuss the role of complement in adaptive immunity in general with a focus on the interplay between CR2-associated antigen on B cells with CR2 expressed on FDCs. This latter interaction provides an opportunity for memory B cells to sample antigen over prolonged periods. The cocrystal structure of CR2 with its ligand C3d provides insight into how the complement system regulates access of antigen by B cells with implications for therapeutic manipulations to modulate aberrant B cell responses in the case of autoimmunity.

PMID:
22921118
PMCID:
PMC5784422
DOI:
10.1016/j.immuni.2012.08.002
[Indexed for MEDLINE]
Free PMC Article

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