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Trends Immunol. 2012 Dec;33(12):590-7. doi: 10.1016/j.it.2012.07.005. Epub 2012 Aug 21.

Heterogeneity in the differentiation and function of memory B cells.

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1
Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Abstract

Vaccines that induce neutralizing antibodies have led to the eradication of small pox and have severely reduced the prevalence of many other infections. However, even the most successful vaccines do not induce protective antibodies in all individuals, and can fail to induce lifelong immunity. A key to remedying these shortcomings may lie in a better understanding of long-lived memory B cells. Recent studies have revealed novel insights into the differentiation and function of these cells, and have shown that the memory B cell pool is much more heterogeneous than previously appreciated.

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PMID:
22920843
PMCID:
PMC3505266
DOI:
10.1016/j.it.2012.07.005
[Indexed for MEDLINE]
Free PMC Article

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